About the project
The global dissemination of multidrug-resistant bacteria represents a major threat to public health. Although bacteriophages might offer an alternative to antibiotics for treating resistant bacterial infections however, the basis of phage-host interaction is not well characterised. Although bacteria may develop resistance against bacteriophages phages can evade these resistance mechanisms. Bacteria-phage interaction is very complex, and a good model is crucial to study the molecular basis of this interaction is required. We use Anderson phage typing scheme for study of bacteria-phage interaction. The system distinguishes more than 300 definitive phage types (DT) of Salmonella Typhimurium based on their patterns of lysis to a unique collection of 30 Salmonella phages. The project aims to use Salmonella Typhimurium phage typing scheme to characterize bacterial antiviral systems in different phage types of Salmonella Typhimurium. Understanding the complex-dynamics of bacteria-phage interaction will provide insights into phage biology and help us to develop an effective and safe phage therapy for the treatment of multidrug resistant bacterial infections.
Funding
This work is an ongoing project and interested applicants including research visitors and/or PhD students are welcome to contact.
Contact
For further information contact the Principal Investigator Dr Manal Mohammed at [email protected].