About the project
HERV-K (Human Endogenous Retrovirus K) molecular studies in Amyotrophic Lateral Sclerosis (ALS) have emerged as a significant area of research, aiming to unravel the potential involvement of these retroviral elements in the pathogenesis of the disease. ALS is a complex neurodegenerative disorder characterised by the progressive degeneration of motor neurons in the brain and spinal cord. Recent evidence suggests that HERV-K, which represents remnants of ancient retroviral infections integrated into the human genome, may play a role in ALS development and progression. By investigating the expression and activity of HERV-K elements in ALS patients, researchers can gain insights into their potential contribution to neuroinflammation, neuronal dysfunction, and motor neuron degeneration observed in the disease. Understanding the molecular interactions between HERV-K and ALS pathology may pave the way for the development of novel diagnostic tools, therapeutic targets, and interventions that could ultimately improve patient outcomes and enhance our understanding of this devastating condition.
Funding
This work is funded by the Amyotrophic Lateral Sclerosis Association (ALSA).
Contact
For further information contact the Principal Investigator Dr. Adele McCormick at [email protected].