Publications

To view our latest publications, visit the Pathobiology and Extracellular Vesicles research group page on WestminsterResearch.

Publications

  • Ansa-Addo EA, Pathak P, McCrossan MV, Volpato Rossi I, Abdullahi M, Stratton D, Lange S, Ramirez MI, Inal JM (2024). Monocyte-derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF-β1. Journal of Extracellular Vesicles, 13, e70014. https://doi.org/10.1002/jev2.70014 
  • Romani A, Antonietti A, Bella D, Budd J, Giacalone E, Kurban K, Sáray S, Abdellah M, Arnaudon A, Boci E, Colangelo C, Courcol JD, Delemontex T, Ecker A, Falck J, Favreau C, Gevaert M, Hernando JB, Herttuainen J, Ivaska G, Kanari L, Kaufmann AK, King JG, Kumbhar P, Lange S, Lu H, Lupascu CA, Migliore R, Petitjean F, Planas J, Rai P, Ramaswamy S, Reimann MW, Riquelme JL, Román Guerrero N, Shi Y, Sood V, Sy MF, Van Geit W, Vanherpe L, Freund TF, Mercer A, Muller E, Schürmann F, Thomson AM, Migliore M, Káli S, Markram H. Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region. PLoS biology, 22(11), e3002861. https://doi.org/10.1371/journal.pbio.3002861 
  • Golluscio A, Eldstrom J, Jowais JJ, Perez ME, Cunningham KP, De La Cruz A, Wu X, Corradi V, Tieleman DP, Fedida D, Larsson HP. PUFA stabilizes a conductive state of the selectivity filter in IKs channels. eLife, 13, RP95852. https://doi.org/10.7554/eLife.95852
  • Ramos-Sevillano E, Ercoli G, Betts M, Guerra-Assunção JA, Iverson A, Frank M, Partridge F, Lo SW, Fernandes VE, Nasher F, Wall E, Wren B, Gordon SB, Ferreira DM, Heyderman R, Rosch J, Brown JS. Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae. mBio, e0175824. https://doi.org/10.1128/mbio.01758-24
  • Ferreira AM, Silva-Álvarez V, Kraev I, Uysal-Onganer P, Lange S. (2024). Extracellular vesicles and citrullination signatures are novel biomarkers in sturgeon (Acipenser gueldenstaedtii) during chronic stress due to seasonal temperature challenge. Fish Shellfish Immunol. 154: 109974. https://doi.org/10.1016/j.fsi.2024.109974
  • Mercer A, Sancandi M, Maclatchy A, Lange S. (2024). Brain-Region-Specific Differences in Protein Citrullination/Deimination in a Pre-Motor Parkinson’s Disease Rat Model. International Journal of Molecular Sciences. 2024; 25(20):11168, https://doi.org/10.3390/ijms252011168  
  • Lange S, Inal JM, Kraev I, Dart DA, Uysal-Onganer P. Low Magnetic Field Exposure Alters Prostate Cancer Cell Properties. Biology (Basel). 2024, 13(9):734. https://doi.org/10.3390/biology13090734
  • Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, Larsson HP, Nimigean CM (2024). Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature. 2024, 632(8024):451-459. doi: 10.1038/s41586-024-07743-z. https://www.nature.com/articles/s41586-024-07743-z
  • Wu X, Cunningham KP, Bruening-Wright A, Pandey S, Larsson HP (2024). Loose Coupling between the Voltage Sensor and the Activation Gate in Mammalian HCN Channels Suggests a Gating Mechanism. Int J Mol Sci. 2024; 25(8):4309. https://doi.org/10.3390/ijms25084309
  • Welsh JA, Goberdhan DCI, O'Driscoll L, et al…MISEV Consortium, Théry C, Witwer KW. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles. 2024;13(2):e12404. doi:10.1002/jev2.12404
  • Lange S (2024). Special Issue Editor: “Extracellular Vesicles in Phylogeny 2.0”. https://www.mdpi.com/journal/ijms/special_issues/0H5Z7E190N
  • Lange S and Inal J (2024). Special Topic Editor: “Animal Models of Human Disease 2.0”. https://www.mdpi.com/topics/4Q38Y4392K

  • Mitra S, Harvey-Jones K, Kraev I, Verma V, Meehan C, Mintoft A, Norris G, Campbell E, Tucker K, Robertson NJ, Hristova M, Lange S (2023). The Extracellular Vesicle Citrullinome and Signature in a Piglet Model of Neonatal Seizures. Int J Mol Sci.24(14):11529.
  • Coates CJ, Kraev I, Rowley AF, Lange S (2023). Extracellular vesicle signatures and protein citrullination are modified in shore crabs (Carcinus maenas) infected with Hematodinium sp. Virulence. 14(1):2180932.
  • Coates CJ, Rowley AF, Lange S (2023). Immunopathology of Hematodinium sp. infection of decapod crustaceans. Dev Comp Immunol 148:104936.
  • Jorfi S, Ansa-Addo EA, Mariniello K, Warde P, Bin Senian AA, Stratton D, Bax BE, Levene M, Lange S, Inal JM (2023). A Coxsackievirus B1-mediated nonlytic Extracellular Vesicle-to-cell mechanism of virus transmission and its possible control through modulation of EV release. J Gen Virol. 2023 104(9).
  • Lange S (2023). Extracellular Vesicles in Phylogeny. Int J Mol Sci. 24 (13), 10466. Romani A, Lange S, Markram H (2023). Community-based Reconstruction and Simulation of a Full-scale Model of Region CA1 of Rat Hippocampus. bioRxiv, 2023.05. 17.541167.
  • Lange S, Inal JM (2023). Animal Models of Human Disease. Int J Mol Sci. 2023;24(21):15821.
  • Ramos-Sevillano E, Ercoli G, … Partridge FA, … Brown JS (2023). Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae bioRxiv 2023.08.03.550501
  • Coghlan A, Partridge FA, Duque-Correa MA, Rinaldi G, Clare S, Seymour L, Brandt C, Mkandawire TT, McCarthy C, Holroyd N, Nick M, Brown AE, Tonitiwong S, Sattelle DB, Berriman M. A drug repurposing screen for whipworms informed by comparative genomics. PLoS Negl Trop Dis. 2023 17(9):e0011205
  • Fard GH, Getting S, Iqbal H, Keshavarz T (2023). iNos and Cox-2 downregulation in melanoma using a-MSH peptide-loaded polysaccharide based nano-emulsion” 2023, (In Prep).
  • Lange S and Knöpfel T (2023). Special Issue Editor: “State-of-the-Art Neurobiology in the U.K.” Int J Mol Sci, Mol Neurobiology 2023, https://www.mdpi.com/journal/ijms/special_issues/Mol_Neurobiol_UK  
  • Lange S and Inal J (2023). Special Topic Editor: “Animal Models of Human Disease”. MDPI https://www.mdpi.com/topics/Model_Animals#information 
  • Lange S (2023). Special Topic Editor: “Extracellular Vesicles in Tissue Remodelling in Health and Disease”, Extracellular Vesicles and Circulating Nucleic Acids,  https://evcna.com/journal/special_detail/1293
  • Lange S (2023). Special Issue Editor: "The Exposome in Immune Evolution, Health and Disease", Biology (Basel), https://www.mdpi.com/journal/biology/special_issues/9HT9A4S4ZO
  • Nazyrova N, Chahed S, Dwek M, Getting SJ, Chaussalet T (2023). Discovering Drug-Drug Interactions Using Association Rule Mining from Electronic Health Records. INISTA Conference Proceedings.
  • Wickstead ES, Elliott BT, Pokorny S, Biggs C, Getting SJ, McArthur S (2023). Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity. Int J Mol Sci. 2023;24(21):15996.

  • Hatakeyama D, Sunada H, Totani Y, Watanabe T, Felletar I, Fitchett A, Eravci M, Anagnostopoulou A, Miki R, Okada A, Abe N, Kuzuhara T, Kemenes I, Ito E, Kemenes G. (2022). Molecular and functional characterization of an evolutionarily conserved CREB-binding protein in the Lymnaea CNS. FASEB J. 36(11):e22593. 
  • Wooller S, Anagnostopoulou A, Kuropka B, Crossley M, Benjamin PR, Pearl F, I Kemenes I, Kemenes G, Eravci M. (2022) A combined bioinformatics and LC-MS-based approach for the development and benchmarking of a comprehensive database of Lymnaea CNS proteins.  J Exp Biol. 225(7):jeb243753.
  • Fard GH, Moinipoor Z, Anastasova-Ivanova S, Iqbal H, Dwek MV, Getting SJ, Keshavarz T (2022). Development of chitosan, pullulan, and alginate based drug-loaded nano-emulsions as a potential malignant melanoma delivery platform. Carbohydrate Polymer Technologies and Applications 4: 100250.
  • Wickstead ES, Irving MA, Getting SJ, McArthur S. (2022). Exploiting formyl peptide receptor 2 to promote microglial resolution: a new approach to Alzheimer's disease treatment. The FEBS Journal. 289 (7): 1801-1822.
  • Morad HOJ, Luqman S, Pinto LG, Cunningham KP, et al. (2022). Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release. Scientific Reports, 12: 11078.
  • Wu X, Ramentol R, Cunningham KP, Perez ME, Larsson HP (2022). New insights into the cAMP modulation of activation and inactivation of HCN channels. Journal of General Physiology – currently addressing minor corrections
  • Mercer A, Jaunmuktane Z, Hristova M, Lange S (2022). Differential, Stage Dependent Detection of Peptidylarginine Deiminases and Protein Deimination in Lewy Body Diseases-Findings from a Pilot Study. Int J Mol Sci. 23(21):13117.
  • Inal JM, Hristova M, Lange S (2022). A Pilot Study on Peptidylarginine Deiminases and Protein Deimination in Animal Cancers across Vertebrate Species. Int J Mol Sci. 23(15):8697.
  • D'Alessio S, Cheng H, Eaton L, Kraev I, Pamenter ME, Lange S (2022). Acute Hypoxia Alters Extracellular Vesicle Signatures and the Brain Citrullinome of Naked Mole-Rats (Heterocephalus glaber). Int J Mol Sci. 23(9):4683.
  • Arisan ED, Dart DA, Grant GH, Dalby A, Kancagi DD, Turan RD, Yurtsever B, Karakus GS, Ovali E, Lange S, Uysal-Onganer P (2022). microRNA 1307 Is a Potential Target for SARS-CoV-2 Infection: An in Vitro Model. ACS Omega. 7(42):38003-38014.
  • Mortoglou M, Miralles F, Arisan ED, Dart A, Jurcevic S, Lange S, Uysal-Onganer P (2022). microRNA-21 Regulates Stemness in Pancreatic Ductal Adenocarcinoma Cells. Int J Mol Sci. 23(3):1275.
  • Nick M, Partridge FA, Forman R, Bataille CJR, Else KJ, Russell AJ, Sattelle DB (2022) Screening the Medicines for Malaria Venture (MMV) Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads Front. Trop. Dis. 2022 3:1017900.
     

  • Yao Z, Getting SJ, Locke IC. (2021). Regulation of TNF-Induced Osteoclast Differentiation. Cells 11(1):132. doi: 10.3390/cells11010132.
  • Cunningham KP, Clapp LH, Mathie A, Veale EL (2021). The prostacyclin analogue, treprostinil, used in the treatment of pulmonary arterial hypertension, is a potent antagonist of TREK-1 and TREK-2 potassium channels. Frontiers in Pharmacology, 12: 1599.
  • Mathie A, Veale EL, Cunningham KP, Holden RG, Wright PD (2021). Two-Pore Domain Potassium Channels as Drug Targets: Anesthesia and Beyond. Annual Review of Pharmacology and Toxicology, 61 (1).
  • Ahmed D, Puthussery H, Basnett P, Knowles JC, Lange S*, Roy I* (2021). Controlled Delivery of Pan-PAD-Inhibitor Cl-Amidine Using Poly(3-Hydroxybutyrate) Microspheres. Int J Mol Sci. 2021; 22(23),12852. *co-corresponding PIs.
  • Kyriakidou Y, Cooper I, Kraev I, Lange S, Elliott B (2021). Preliminary Investigations into the Effect of Exercise-Induced Muscle Damage on Systemic Extracellular Vesicle Release in Trained Younger and Older Men. Frontiers Physiology, 12, 723931. 
  • D’Alessio S, Buckley KM, Kraev I, Hayes P, Lange S (2021). Extracellular Vesicle Signatures and Post-Translational Protein Deimination in Purple Sea Urchin (Strongylocentrotus purpuratus) Coelomic Fluid—Novel Insights into Echinodermata Biology. Biology. 10(9), 866. 
  • Rast JP, D'Alessio S, Kraev I, Lange S (2021). Post-translational protein deimination signatures in sea lamprey (Petromyzon marinus) plasma and plasma-extracellular vesicles. Dev Comp Immunol. 125, 104225. 
  • Lange S (2021). Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair. Neural Regen Res. 16(5), 934-938. 
  • Uysal-Onganer P, D'Alessio S, Mortoglou M, Kraev I, Lange S (2021). Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures. Int J Mol Sci. 22(3), 1396. 
  • Arisan ED, Rencuzogullari O, Cieza-Borrella C, Miralles Arenas F, Dwek M, Lange S, Uysal-Onganer P (2021). MiR-21 Is Required for the Epithelial-Mesenchymal Transition in MDA-MB-231 Breast Cancer Cells. Int J Mol Sci. 22(4), 1557. 
  • Lange S, Arisan ED, Grant GH, Uysal-Onganer P (2021). MicroRNAs for Virus Pathogenicity and Host Responses, Identified in SARS-CoV-2 Genomes, May Play Roles in Viral-Host Co-Evolution in Putative Zoonotic Host Species. Viruses. 13(1),117.
  • Kristmundsson Á, Erlingsdóttir Á, Lange S (2021). Peptidylarginine Deiminase (PAD) and Post-Translational Protein Deimination—Novel Insights into Alveolata Metabolism, Epigenetic Regulation and Host–Pathogen Interactions. Biology (Basel). 10(3),177. 
  • D’Alessio S, Thorgeirsdóttir S, Kraev I, Skírnisson K, Lange S (2021). Post-Translational Protein Deimination Signatures in Plasma and Plasma EVs of Reindeer (Rangifer tarandus). Biology. 10(3), 222. 
  • Lange S, Ramirez MI (2021). Editorial: Tissue Remodeling in Health and Disease Caused by Bacteria, Parasites, Fungi, and Viruses. Front Cell Infect Microbiol. 11:642311. 
  • Magnadóttir B, Kraev I, Dodds AW, Lange S (2021). The Proteome and Citrullinome of Hippoglossus hippoglossus Extracellular Vesicles-Novel Insights into Roles of the Serum Secretome in Immune, Gene Regulatory and Metabolic Pathways. Int J Mol Sci. 22(2),875. 
  • Forman R, Partridge FA, Sattelle DB, Else KJ (2021). Un-‘Egg’-Plored: Characterisation of Embryonation in the Whipworm Model Organism Trichuris muris. Frontiers in Tropical Diseases 2, 45. 
  • Partridge FA, Poulton BC, Lake, MAI, Lees, RA, Mann H-J, Lycett GJ, Sattelle (2021). Actions of camptothecin derivatives on larvae and adults of the arboviral vector Aedes aegypti. Molecules 26, 6226.
  • Buckingham SD, Partridge FA, Poulton BC, Miller BS, McKendry RA, Lycett GJ, Sattelle DB (2021). Automated phenotyping of mosquito larvae enables high-throughput screening for novel larvicides and smartphone-based detection of larval insecticide resistance. PLOS Negl Trop Dis 15(6): e0008639. 
  • Partridge FA, Bataille CJR, Forman R, Marriott AE, Forde-Thomas J, Häberli C, Dinsdale RL, O’Sullivan JDB, Willis N, Wynne GM, Whiteland H, Archer J, Steven A, Keiser J, Turner JD, Hoffmann KF, Taylor MJ, Else KJ, Russell AJ, Sattelle DB (2021). Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites - Trichuris muris, Brugia malayi, Heligmosomoides polygyrus and Schistosoma mansoni. ACS Infectious Diseases 2021 7, 1260−1274.
  • Lange S (2021). Extracellular vesicle signatures in diverse taxa across phylogeny. UK Extracellular Vesicle Society Annual Meeting, 13-14th December 2021, At: UK EV Virtual Forum.
  • Lange S and Bracha S (2021) Special issue Editor: “Cancers across Phylogeny and Cancer Evolution” Int J Mol Sci 2021, https://www.mdpi.com/journal/ijms/special_issues/Cancers_Phylogeny_Evolution
  • Lange S (2021) Special issue Editor: “Extracellular Vesicles in Phylogeny” Int J Mol Sci, Biochemistry 2021, https://www.mdpi.com/journal/ijms/special_issues/ExtracellularVesicle_Phylogeny
  • Lange S and Ramirez MI (2021). Research Topic Editor: “Tissue Remodelling in Health and Disease caused by Bacteria, Parasites, Fungi and Viruses”, Front Cell Infect Microbiol https://www.frontiersin.org/research-topics/11029/tissue-remodeling-in-health-and-disease-caused-by-bacteria-parasites-fungi-and-viruses
     

  • Anagnostopoulou A, Camargo LL, Rodrigues D, Montezano AC, Touyz RM (2020). Importance of cholesterol-rich microdomains in the regulation of NOX isoforms and redox signaling in human vascular smooth muscle cells. Sci Rep. 10(1): 17818-17838. 
  • Alves-Lopes R, Neves KB, Anagnostopoulou A, Rios FJ, Lacchini S, Montezano AC, Touyz RM (2020). Crosstalk Between Vascular Redox and Calcium Signaling in Hypertension Involves TRPM2 (Transient Receptor Potential Melastatin 2) Cation Channel. Hypertension. 75(1):139-149.
  • Can V, Locke IC, Kaneva M, Kerrigan MJP, Merlino F, De Pascale C, Grieco P, Getting SJ (2020). Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated. Eur J. Pharmacol (872); 172971.
  • Wickstead E, Getting SJ, Biggs CS, McArthur S (2020). Reversal of beta-Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/3. Oxidative Medicine and Cellular Longevity. 2020, 2139192. 
  • Cunningham KP, MacIntyre DE, Veale EL, Mathie A (2020). Effects of the ventilatory stimulant, doxapram on human TASK-3 (KCNK9, K2P9.1) channels and TASK-1 (KCNK3, K2P3.1) channels. Acta Physiol, 228 (2): e13361.
  • Wickstead E, Getting SJ, Biggs CS, McArthur S. (2020). Reversal of beta-Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/3. Oxidative Medicine and Cellular Longevity. 2020 2139192. 
  • Sancandi M, Kraev I, Mercer A, Lange S (2020). Protein Deimination Signatures in Plasma and Plasma-EVs and Protein Deimination in the Brain Vasculature in a Rat Model of Pre-Motor Parkinson's Disease. Int J Mol Sci. 21(8), 2743.
  • Arisan ED, Uysal-Onganer P, Lange S (2020). Putative Roles for Peptidylarginine Deiminases in COVID-19. Int J Mol Sci. 21(13):E4662. 
  • Arisan ED, Dart A, Grant GH, Arisan S, Cuhadaroglu S, Lange S, Uysal-Onganer P (2020). The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for Comorbidities. Viruses. 12(6):614. 
  • Ecker A, Romani A, Sáray S, Káli S, Migliore M, Falck J, Lange S, Mercer A, Thomson AM, Muller E, Reimann MW, Ramaswamy S (2020). Data-driven integration of hippocampal CA1 synaptic physiology in silico. Hippocampus. 30(11), 1129-1145. 
  • Uysal-Onganer P, MacLatchy A, Kraev I, Thompson PR, Inal JM, Lange S (2020). Peptidylarginine deiminase isozyme-specific inhibitors differentially modulate extracellular vesicle signatures and cell Invasion in two glioblastoma multiforme cell lines. Int J Mol Sci. 21(4), E1495. 
  • Antwi-Baffour S, Malibha-Pinchbeck M, Stratton D, Lange S, Inal J (2020).  Plasma mEV levels in Ghanaian malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets. J Extracell Ves. 9 (1), 1697124. 
  • Criscitiello M, Kraev I, Lange S (2020). Post-translational Protein Deimination Signatures in Serum and Serum-Extracellular Vesicles of Bos taurus reveal immune, anti-pathogenic, anti-viral, metabolic and cancer-related pathways for deimination. Int J Mol Sci. 21(8), 2861. 
  • Gavinho B, Sabatke B, Feijoli V, Rossi IV, da Silva JM, Evans-Osses I, Palmisano G, Lange S, Ramirez MI (2020). Peptidylarginine Deiminase Inhibition Abolishes the Production of Large Extracellular Vesicles From Giardia intestinalis, Affecting Host-Pathogen Interactions by Hindering Adhesion to Host Cells. Front Cell Infect Microbiol. 10:417. 
  • Bowden TJ, Kraev I, Lange S (2020). Extracellular Vesicles and Post-Translational Deimination Signatures in Mollusca- Blue Mussel (Mytilus edulis), Soft Shell Clam (Mya arenaria), Eastern Oyster (Crassostrea virginica), Atlantic Jacknife Clam (Ensis leei). Biology (Basel). 9(12):E416. 
  • Bowden TJ, Kraev I, Lange S (2020). Extracellular vesicles and post-translational protein deimination signatures in haemolymph of American lobster (Homarus americanus). Fish Shellfish Immunol. 106:79-102. 
  • Bowden TJ, Kraev I, Lange S (2020). Post-translational protein deimination signatures and extracellular vesicles (EVs) in the Atlantic horseshoe crab (Limulus polyphemus). Dev Comp Immunol. 110:103714. 
  • Magnadóttir B, Uysal Onganer P, Kraev I, Dodds AW, Gudmundsdottir S, Lange S (2020). Extracellular vesicles, deiminated protein cargo and microRNAs are novel serum biomarkers for environmental rearing temperature in Atlantic cod (Gadus morhua L.). Aquaculture Rep. 16, 100245. 
  • Criscitiello M, Kraev I, Petersen LH, Lange S (2020). Deimination Protein Profiles in Alligator mississippiensis reveal plasma and extracellular vesicle- specific signatures relating to immunity, metabolic function and gene regulation. Front Immunol. 11:651. 
  • Phillips RA, Kraev I, Lange S (2020). Protein Deimination and Extracellular Vesicle Profiles in Antarctic Seabirds. Biology (Basel). 9(1):15. 
  • Magnadóttir B, Uysal-Onganer P, Kraev I, Svansson V, Hayes P, Lange S (2020). Deiminated proteins and extracellular vesicles - Novel serum biomarkers in whales and orca. Comp Biochem Physiol Part D Genomics Proteomics. 34, 100676. 
  • Magnadóttir B, Uysal-Onganer P, Kraev I, Svansson V, Skírnisson K, Lange S (2020). Deiminated proteins and extracellular vesicles as novel biomarkers in pinnipeds: Grey seal (Halichoerus gryptus) and harbour seal (Phoca vitulina). Biochimie. 171-172:79-90. 
  • Criscitiello M, Kraev I, Lange S (2020). Deiminated proteins in EVs and serum of Llama (Lama glama) – novel insights into camelid immunity. Mol Immunol. 117: 37-53. 
  • Partridge FA, Forman R, Bataille CJR, Wynne GM, Nick M, Russell AJ, Else KJ, Sattelle DB (2020). Anthelmintic drug discovery: target identification, screening methods and the role of open science. Beilstein J. Org. Chem. 16, 1203–1224.
  • Lange S (2020). PADs, post-translational deimination and extracellular vesicle signatures in diverse taxa across phylogeny. Wild and Comparative Immunology Workshop (WACI). Abstract P31. Online
  • D’Alessio S, Thorgeirsdottir S, Kraev I, Lange S (2020). Deiminated proteins and extracellular vesicle profiling in reindeer (Rangifer tarandus). Wild and Comparative Immunology Workshop (WACI). Abstract P29 Online

  • Cunningham KP, Holden RG, Escribano-Subias PM, Cogolludo A, Veale EL, Mathie A (2019). Characterization and regulation of wild-type and mutant TASK-1 two pore domain potassium channels indicated in pulmonary arterial hypertension. The Journal of Physiology, 597 (4): 1087 – 1101.
  • Sisa C, Kholia S, Naylor J, Herrera Sanchez MB, Bruno S, Deregibus MC, Camussi G, Inal JM, Lange S*, Hristova M* (2019). Mesenchymal Stromal Cell Derived Extracellular Vesicles Reduce Hypoxia-Ischaemia Induced Perinatal Brain Injury. Front Physiol. 10, 282. *co-corresponding PIs. 
  • Rocha-Ferreira E, Sisa C, Bright S, Fautz T, Harris M, Contreras Riquelme I, Agwu C, Kurulday T, Mistry B, Hill D, Lange S, Hristova M (2019). Curcumin: Novel Treatment in Neonatal Hypoxic-Ischemic Brain Injury. Front Physiol. 10:1351. 
  • Kosgodage US, Uysal-Onganer P, MacLatchy A, Mould R, Nunn AV, Guy GW, Kraev I, Chatterton NP, Thomas EL, Inal JM, Bell JD, Lange S (2019). Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells. Transl Oncol. 12(3):513-522. 
  • Magnadóttir B, Bragason BT, Bricknell IR, Bowden T, Nicholas AP, Hristova M, Guðmundsdóttir S, Dodds AW, Lange S (2019). Peptidylarginine deiminase and deiminated proteins are detected throughout early halibut ontogeny - Complement components C3 and C4 are post-translationally deiminated in halibut (Hippoglossus hippoglossus L.). Dev Comp Immunol. 92:1-19. 
  • Magnadóttir B, Gudmundsdóttir S, Lange S (2019). A novel ladder-like lectin relates to sites of mucosal immunity in Atlantic Halibut (Hippoglossus hippoglossus L.) Fish Shellfish Immunol. 87:9-12. 
  • Lange S, Kraev I, Magnadóttir B, Dodds AW (2019). Complement component C4-like protein in Atlantic cod (Gadus morhua L.) - Detection in ontogeny and identification of post-translational deimination in serum and extracellular vesicles. Dev Comp Immunol. 101:103437. 
  • Magnadóttir B, Kraev I, Guðmundsdóttir S, Dodds AW, Lange S (2019). Extracellular vesicles from cod (Gadus morhua L.) mucus contain innate immune factors and deiminated protein cargo. Dev Comp Immunol. 99:103397. 
  • Criscitiello MF, Kraev I, Lange S (2019). Deiminated proteins in extracellular vesicles and plasma of nurse shark (Ginglymostoma cirratum) - Novel insights into shark immunity. Fish Shellfish Immunol. 92:249-255. 
  • Pamenter ME, Uysal-Onganer P, Huynh KW, Kraev I, Lange S (2019). Post-Translational Deimination of Immunological and Metabolic Protein Markers in Plasma and Extracellular Vesicles of Naked Mole-Rat (Heterocephalus glaber). Int J Mol Sci. 20(21):5378. 
  • Kosgodage US, Matewele P,  Mastroianni G,  Brotherton D,  Awamaria B, Nicholas AP, Lange S*, Inal, JM.* (2019). Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitise Bacteria to Antibiotic Treatment. Front Cell Infect Microbiol. 9:227. *co-corresponding PIs. 
  • Kosgodage US, Matewele P, Awamaria B, Kraev I, Warde P, Mastroianni G, Nunn AV, Guy GW, Bell JD, Inal JM, Lange S (2019). Cannabidiol Is a Novel Modulator of Bacterial Membrane Vesicles. Front Cell Infect Microbiol. 9:324. 
  • Can VC, Locke IC, Grieco P, Getting SJ (2019). The effect of melanocortin peptides on high density human chondrocyte micromass cultures activated by IL-1beta. 02/05/2019 – 05/05/2019 OARSI World Congress China Evening Toronto, Canada  
  • Can VC, Locke IC, Grieco P, Getting,SJ (2019). The effect of PG-990 on high density human chondrocyte micromass cultures activated by IL-1.05/10/2019-08/10/2019 ICRS, Vancouver Canada
  • De Pascale C, Marcello E, Getting SJ, Roy I, Locke IC (2019). Populated collagen hydrogel and Polyhydroxyalkanoate composites: novel matrices for cartilage repair and regeneration? Osteoartritis and cartilage. 27(1), 432-433.
  • De Pascale C, Getting SJ, Locke IC (2019). Effect of Urocortin on human osteoclasts differentiation. British Journal of Pharmacology, August 2019, Volume 176, Issue 16.
  • De Pascale C, Getting SJ, Locke IC (2019). The effect of Urocortin on osteoclasts and chondrocytes: a possible application in cartilage regeneration in contained osteoarthritic lesions? BBSRC conference, Scotland 18-19 June 2019.
  • Fard GH, Dwek MV, Getting S, Iqbal H, Keshavarz T (2019). Evaluation of doxorubicin-loaded composite nano-emulsion’s uptake in malignant melanoma. Biomaterials and Tissue engineering, Gordon Research Conference 2019. 
  • Fard GH, Dwek MV, Getting S, Iqbal H, Keshavarz T (2019). Evaluation of doxorubicin-loaded composite nano-emulsion’s uptake in malignant melanoma. Skin@Bath symposium December 2019.
  • Faravelli G, Raimondi S, Marchese L, Partridge FA, Soria C, Mangione PP, Canetti D, Perni M, Aprile FA, Zorzoli I, Di Schiavi E, Lomas DA, Bellotti V, Sattelle DB, Giorgetti S (2019).  C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis. Sci Rep 9, 1–10.
  • Touyz RM, Anagnostopoulou A, Rios F, Montezano AC, Camargo LL (2019). Nox5: Molecular Biology and Pathophysiology. Exp Physiol. 104(5):605-616. 
  • Touyz RM, Anagnostopoulou A, Camargo LL, Rios FJ, Montezano AC (2019). Vascular Biology of Superoxide-Generating NADPH Oxidase 5-Implications in Hypertension and Cardiovascular Disease. Antioxid Redox Signal. 30(7):1027-1040.
  • Lange S (2020). Special issue Editor: “PADs and Protein Deimination in Health and Disease” Int J Mol Sci, https://www.mdpi.com/journal/ijms/special_issues/Peptidylarginine_Deiminases 

  • Momen Heravi F, Getting SJ, Moschos SA (2018). Extracellular vesicles and their nucleic acids for biomarker discovery. Pharmacology and Therapeutics. S0163-7258 (18) 30134-30137.
  • Kosgodage US, Uysal-Onganer P, MacLatchy A, Kraev I, Chatterton NP, Nicholas AP, Inal JM, Lange S (2018). Peptidylarginine Deiminases Post-Translationally Deiminate Prohibitin and Modulate Extracellular Vesicle Release and MicroRNAs in Glioblastoma Multiforme. Int J Mol Sci. 20(1), 103. 
  • Migliore R, Lupascu CA, Bologna LL, Romani A, Courcol JD, Antonel S, Van Geit WAH, Thomson AM, Mercer A, Lange S, Falck J, Rössert CA, Shi Y, Hagens O, Pezzoli M, Freund TF, Kali S, Muller EB, Schürmann F, Markram H, Migliore M (2018). The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow. PLoS Comput Biol. 14(9), e1006423. 
  • Kosgodage US, Mould R, Henley AB, Nunn AV, Guy GW, Thomas EL, Inal JM, Bell JD, Lange S (2018). Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer. Front Pharmacol. 9:889. 
  • Magnadóttir B, Hayes P, Hristova M, Bragason BT, Nicholas AP, Dodds AW, Guðmundsdóttir S, Lange S (2018). Post-translational protein deimination in cod (Gadus morhua L.) ontogeny novel roles in tissue remodelling and mucosal immune defences? Dev Comp Immunol. 87:157-170. 
  • Magnadóttir B, Hayes P, Gísladóttir B, Bragason BÞ, Hristova M, Nicholas AP, Guðmundsdóttir S, Lange S (2018). Pentraxins CRP-I and CRP-II are post-translationally deiminated and differ in tissue specificity in cod (Gadus morhua L.) ontogeny. Dev Comp Immunol. 87:1-11. 
  • Romani A, Antille N, Bologna LL, Budd J, Courcol JD, Devresse A, Ecker A, Falck J, Favreau C, Gevaert M, Gulyas AI, Hagens O, Hernando J, Jimenez S, Kanari L, King JG, Lange S, Lupascu CA, Migliore R, Pezzoli M, Povolosky A, Ramaswamy S, Reimann M, Rossert CA, Saray S, Shi Y, Van Geit WAH, Vanherpe L, Freund TF, Kali S, Markram H, Mercer A, Migliore M, Thomson AM, Muller EB (2018). Reconstruction and Simulation of a full-scale Model of Rat Hippocampus CA1. Society for Neuroscience, 2018, 3-7th Nov 2018, San Diego, USA. Online. 
  • Montezano AC, De Lucca Camargo, Persson P, Rios FJ, Harvey AP, Anagnostopoulou A, Palacios R, Gandara ACP, Alves-Lopes R, Neves KB, Dulak-Lis M, Holterman CE, de Oliveira PL, Graham D, Kennedy C, Touyz RM (2018). NADPH Oxidase 5 Is a Pro-Contractile Nox isoform and a Point of Cross-Talk for Calcium and Redox Signalling-Implications in Vascular Function. J Am Heart Assoc. 7(12):e009388. 
  • Touyz RM, Alves-Lopes R, Rios FJ, Camargo LL, Anagnostopoulou A, Arner A, Montezano AC (2018). Vascular smooth muscle contraction in hypertension. Cardiovasc Res. 15:114(4): 529-539.
  • Matthews BJ, Dudchenko O, Kingan SB, … Partridge FA,… Vosshall (2018). Improved reference genome of Aedes aegypti informs arbovirus vector control. Nature 2018 563:501-507.
  • Partridge FA, Forman R, Willis NJ, Bataille CJR, Murphy EA, Brown AE, Heyer-Chauhan N, Marinič B, Sowood DJC, Wynne GM, Else KJ, Russell AJ, Sattelle DB (2018). 2,4-Diaminothieno[3,2-d]pyrimidines, a New Class of Anthelmintic with Activity against Adult and Egg Stages of Whipworm. PLoS Negl Trop Dis 12(7):e0006487 
  • Furutani S, Ihara M, Lees K, Buckingham SD, Partridge FA, David JA, Patel R, Warchal S, Mellor IR, Matsuda K, Sattelle DB. (2018) The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease. International Journal for Parasitology: Drugs and Drug Resistance. 8(2):350-360 
  • Partridge FA, Brown AE, Buckingham SD, Willis NJ, Wynne GM, Forman R, Else KJ, Morrison AA, Matthews JB, Russell AJ, Lomas DA, Sattelle DB (2018). An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes. International Journal for Parasitology: Drugs and Drug Resistance 8(1):8-21

  • Lange S, Gallagher M, Kholia S, Kosgodage US, Hristova M, Hardy J, Inal JM (2017). Peptidylarginine Deiminases-Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release? Int J Mol Sci. 18(6),1196. 
  • Lange S, Wray S, Devine M, Matarin M, Hardy J (2017). Protein Deimination in Protein Misfolding Disorders – Modelled in Human Induced Pluripotent Stem Cells (iPSCs). In: Protein Deimination in Human Health and Disease, Volume II (Bhattacharya, S; Nicholas, A (Eds.)), Chapter 13. Springer, ISBN10 3319582437. 
  • Kosgodage US, Trindade RP, Thompson PT, Inal JM, Lange S (2017). Chloramidine /Bisindolylmaleimide-I- Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy. Int J Mol Sci. 18(5). 
  • Moore C, Kosgodage U, Lange S, Inal JM (2017). The emerging role of exosome and microvesicle- (EMV-) based cancer therapeutics and immunotherapy. Int J Cancer. 141(3):428-436. 
  • Lange S, Kholia S, Kosgodage US, Inal JM (2017). Treatment of Prostate Cancer Using Deimination Antagonists and Microvesicle Technology. In: Protein Deimination in Human Health and Disease, Volume II (Bhattacharya, S; Nicholas, A (Eds.)), Chapter 22. Springer ·ISBN10 3319582437. 
  • Romani A, Antille N, Atenekeng G, Courcol JD, Devresse A, Dynes JA, Ecker A, Falck J, Favreau CPH, Gevaert M, Gulyas A, Hernandi JB, Jimenez S, Kali S, Kanari L, King JG, Lange S, Lu H, Lupascu C, Mercer A, Migliore M, Migliore R, Povolotskiy A, Ramaswamy S, Reimann M, Riquelme RL, Rössert CA, Thomson AM, Van Geit WAH, Vanherpe L, Markram H, Muller EB (2017). Reconstruction and Simulation of a Full-scale Model of Rat Hippocampus. Society for Neuroscience, 2017, 11-15th Nov 2017, Washington DC, USA. Online. BMC Neuroscience 18(1), 1-82. 
  • De Pascale C, Getting SJ, Locke IC (2017). Expression of the Urocortin system in human bone and cartilage cells. Daphne Jackson Trust research conference, Royal Society, London, United Kingdom 4th of Nov 2017. 
  • Can VC, Locke IC, Grieco P, Getting SJ (2017). The effect of the selective human MC3 receptor agonist PG992 on high density human chondrocyte micromass cultures activated by IL-1beta. Pharmacology 2017. London, U.K. 11 - 13 Dec 2017 British Pharmacological Society.
  • Can VC, Abouelnour A, Locke IC, Bligh SWA, Getting SJ (2017). The effect of silymarin on chondrocytes. ICMAN/ IUPHAR Natural Products. Aberdeen, Scotland 27 - 29 Sep 2017 Elsevier. https://doi.org/10.1016/j.bcp.2017.06.036
  • Wickstead E, Getting SJ, Biggs CS, McArthur S (2017). Reversal of β-amyloid induced microglial activation by an agonist of Fpr2. British Pharmacological Society: Pharmacology 2017. London 11 - 13 Dec 2017.
  • Wickstead E, Getting SJ, Biggs CS, McArthur S (2017). Activation of the pro-resolving receptor Fpr2 attenuates inflammatory microglial activation. BNA Festival of Neuroscience. Birmingham 10 - 13 Apr 2017 Sage. https://doi.org/10.1177/2398212817705279
  • Getting SJ, Can VC, Locke IC, Grieco P (2017). The effect of the selective MC3 agonist PG990 on high density human chondrocytes micromass cultures activated by TNF-alpha. World Congress on Inflammation. London 08 - 12 Jul 2017.
  • Wickstead E, Getting SJ, Biggs CS, McArthur S (2017). Fpr2 and neuroinflammation: selective agonists with synergistic anti-oxidative and pro-resolving effects. World Congress on Inflammation. London 08 - 12 Jul 2017.
  • Wickstead E, Getting SJ, Biggs CS, McArthur S (2017). Fpr2: a novel drug target to tackle oxidative stress and inflammation in Alzheimer’s disease. Alzheimer’s Research UK 2017 Conference, Aberdeen.
  • Partridge FA, Murphy EA, Willis NJ, Bataille CJ, Forman R, Heyer-Chauhan N, Marinič B, Sowood DJ, Wynne GM, Else KJ, Russell AJ, Sattelle DB (2017). Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo. PLoS Negl Trop Dis. 11(2):e0005359.

  • Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F, Perretti M, D'Amico M, Di Filippo C (2016). Activation of Melanocortin Receptors MC 1 and MC 5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy. Mediators Inflamm. 2016:7368389.
  • Lange S (2016). Peptidylarginine Deiminases as Drug Targets in Neonatal Hypoxic-Ischaemic Encephalopathy. Front Neurol. 7:22. 
  • Romani A, Antille N, Atenekeng G, Courcol JD, Devresse A, Dynes JA, Falck J, Gevaert M, Gonzalo JK, Gulyas A, Kali S, Kanari L, Lange S, Mercer A, Migliore M, Muller EB, Palacios JP, Ramaswamy S, Reimann M, Riquelme RL, Rössert CA, Ying S, Shillcock J, Telefont M, Van Geit WAH, Vanherpe L, Markram H, Thomson A (2016). A data-driven model of the hippocampus using the HBP Brain Simulation Platform. 10th FENS Forum of Neuroscience July 2-6, 2016 Copenhagen, Denmark. FENS Abstr. Vol http://emdstudio.co.il/ebook/fens2016/files/basichtml/page134.html 
  • Lange S, Kosgodage U, Inal JM (2016). Non-phagocytic epithelial cells take up microvesicles by micropinocytosis (PF7.09). The Fifth International Meeting of ISEV, Rotterdam, Netherlands 4-7th May 2016. J Extracellular Vesicles 5,172. 
  • Lange S, Kosgodage U, Inal JM (2016). Inhibitors of microvesicle release with the potential to enhance effectivity of cancer chemotherapy (PW1.04). The Fifth International Meeting of ISEV, Rotterdam, Netherlands 4-7th May. J Extracellular Vesicles 5, 34.  
  • Nguyen Dinh Cat A, Antunes TT, Callera GT, Sanchez A, Tsiropoulou S, Dulak-Lis MG, Anagnostopoulou A, He Y, Montezano AC, Jaisser F, Touyz RM (2016). Diabetes. 65(8): 2392-403.
  • Touyz RM, Anagnostopoulou A, De Lucca Camargo L, Montezano AC (2016). Novel Biosensors Reveal a Shift in the Redox Paradigm From Oxidative to Reductive Stress in Heart Disease. Circ Res. 119(9):969-971.
  • Can VC, Locke IC, Getting SJ (2016). Effects of the selective MC3 agonists PG990 and PG992 on Interleukin-1beta induced chondrocyte cell death and pro-inflammatory cytokine release. British Pharmacological Society: Pharmacology 2016. London 13 - 15 Dec 2016.
  • Wickstead E, Getting SJ, McArthur S (2016). The formyl peptide receptor 2 (Fpr2) agonist, Compound 43 (Cpd43), attenuates and promotes the release of pro-inflammatory, and anti-inflammatory cytokines, respectively. British Pharmacological Society: Pharmacology 2016. London 13 - 15 Dec 2016
  • Can VC, Locke IC, Getting SJ (2016). The effects of selective MC3 agonist PG990 and PG992 on TNF-alpha induced chondrocyte cell death and pro-inflammatory cytokine release. 7th European Congress of Pharmacology Istanbul, Turkey. 26/06/2016 - 30/06/2016

  • Holloway PM, Durrenberger PF, Trutschl M, Cvek U, Cooper D, Orr AW, Perretti M, Getting SJ, Gavins FN (2015). Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment. Arterioscler Thromb Vasc Biol. 35(9):1936-44.
  • Kholia S, Jorfi S, Thompson PR, Causey CP, Nicholas AP, Inal J, Lange S (2015). A Novel Role for Peptidylarginine Deiminases (PADs) in Microvesicle Release: A Therapeutic Potential for PAD Inhibitors to Sensitize Prostate Cancer Cells to Chemotherapy. J Extracellular Vesicles; 4, 26192.  
  • Jorfi S, Ansa-Addo E, Kholia S, Stratton D, Valley S, Lange S, Inal J (2015). Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo. Scientific Reports 5:13006. 
  • Stratton D, Moore C, Antwi-Baffour S, Lange S, Inal J (2015). Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9. Biochem Biophys Res Commun. 460(3):589-95. 
  • Stratton D, Moore C, Zheng L, Lange S, Inal J (2015). Prostate cancer cells stimulated by calciummediated activation of protein kinase C undergo a refractory period before re-releasing calciumbearing microvesicles. Biochem Biophys Res Commun. 460(3):511-7. 
  • Romani A, Antille N, Mercer A, Dynes JA, Falk J, Gevaert M, Gonzalo JK, Kali S, Kanari L, Migliore M, Lange S, Muller EB, Ramaswamy S, Reimann M, Riquelme RJL, Rössert CA, Shi Y, Telefont M, Van Geit WAH, Markram H, Thomson A (2015). Data-driven Hippocampus CA1 Modeling in the Human Brain Project. 727.19/BB69. 2015 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2015. Online. 
  • Johansen AK, Dean A, Morecroft I, Hook D, Nilsen M, Loughlin L, Anagnostopoulou A, Touyz RM, White K, MacLean MR (2016). The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1. (2016). Pulm Circ. 6(1): 82-92.
  • Kolisek M, Montezano AC, Sponder G, Anagnostopoulou A, Vormann J, Touyz RM, Aschenbach JR (2015). Clin Sci. 129(12): 1143-50.
  • Neves KB, Nguyen Dinh Cat A, Lopes RA, Rios FJ, Anagnostopoulou A, Lobato NS, de Oliveira AM, Tostes RC, Montezano AC, Touyz RM (2015). Chemerin Regulates Crosstalk Between Adipocytes and Vascular Cells Through NOX. Hypertension. 66(3): 657-66.
  • Can VC, Locke IC, Getting SJ (2015). The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation. Physiology 2015. Cardiff, UK. 

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