Pathobiology and Extracellular Vesicles Research Group

About the group

The Pathobiology and Extracellular Vesicles research group, within the Research Centre for Resilience, is based in the University of Westminster's School of Life Sciences. The research group aims to unravel the interplay of innate, adaptive, and epigenetic contribution to pathobiological processes, leading to the identification of novel molecular targets and therapies to improve human health during their lifespan and to expand our understanding of the One Health concept. 

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Projects and initiatives

Find out about the funded projects undertaken by the Pathobiology and Extracellular Vesicles research group

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Publications

Pathobiology and Extracellular Vesicles' recent publications include:

  • Romani A, Antonietti A, Bella D, Budd J, Giacalone E, Kurban K, Sáray S, Abdellah M, Arnaudon A, Boci E, Colangelo C, Courcol JD, Delemontex T, Ecker A, Falck J, Favreau C, Gevaert M, Hernando JB, Herttuainen J, Ivaska G, Kanari L, Kaufmann AK, King JG, Kumbhar P, Lange S, Lu H, Lupascu CA, Migliore R, Petitjean F, Planas J, Rai P, Ramaswamy S, Reimann MW, Riquelme JL, Román Guerrero N, Shi Y, Sood V, Sy MF, Van Geit W, Vanherpe L, Freund TF, Mercer A, Muller E, Schürmann F, Thomson AM, Migliore M, Káli S, Markram H. Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region. PLoS biology, 22(11), e3002861. https://doi.org/10.1371/journal.pbio.3002861 
  • Golluscio A, Eldstrom J, Jowais JJ, Perez ME, Cunningham KP, De La Cruz A, Wu X, Corradi V, Tieleman DP, Fedida D, Larsson HP. PUFA stabilizes a conductive state of the selectivity filter in IKs channels. eLife, 13, RP95852. https://doi.org/10.7554/eLife.95852
  • Ramos-Sevillano E, Ercoli G, Betts M, Guerra-Assunção JA, Iverson A, Frank M, Partridge F, Lo SW, Fernandes VE, Nasher F, Wall E, Wren B, Gordon SB, Ferreira DM, Heyderman R, Rosch J, Brown JS. Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae. mBio, e0175824. https://doi.org/10.1128/mbio.01758-24
  • Ferreira AM, Silva-Álvarez V, Kraev I, Uysal-Onganer P, Lange S. (2024). Extracellular vesicles and citrullination signatures are novel biomarkers in sturgeon (Acipenser gueldenstaedtii) during chronic stress due to seasonal temperature challenge. Fish Shellfish Immunol. 154, 109974. https://doi.org/10.1016/j.fsi.2024.109974
  • Mercer A, Sancandi M, Maclatchy A, Lange S. (2024). Brain-Region-Specific Differences in Protein Citrullination/Deimination in a Pre-Motor Parkinson’s Disease Rat Model. International Journal of Molecular Sciences. 2024; 25(20):11168, https://doi.org/10.3390/ijms252011168
  • Lange S, Inal JM, Kraev I, Dart DA, Uysal-Onganer P. Low Magnetic Field Exposure Alters Prostate Cancer Cell Properties. Biology (Basel). 2024, 13(9):734. https://doi.org/10.3390/biology13090734
  • Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, Larsson HP, Nimigean CM (2024). Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature. 2024, 632(8024):451-459. doi: 10.1038/s41586-024-07743-z. https://www.nature.com/articles/s41586-024-07743-z
  • Wu X, Cunningham KP, Bruening-Wright A, Pandey S, Larsson HP (2024). Loose Coupling between the Voltage Sensor and the Activation Gate in Mammalian HCN Channels Suggests a Gating Mechanism. Int J Mol Sci. 2024; 25(8):4309. https://doi.org/10.3390/ijms25084309
  • Welsh JA, Goberdhan DCI, O'Driscoll L, et al…MISEV Consortium, Théry C, Witwer KW. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles. 2024;13(2):e12404. doi:10.1002/jev2.12404

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Our location

The Pathobiology and Extracellular Vesicles research group is part of the Research Centre for Optimal Health, located within the University of Westminster’s School of Life Sciences, 115 New Cavendish Street, London W1W 6UW.