Proteins are involved in biological processes both in health and disease, where some roles are facilitated, or caused by, post-translational modifications of proteins.
In this inaugural lecture Professor Sigrun Lange will discuss her research journey over two decades, unravelling novel roles for proteins and protein modifications in developmental, regenerative and disease processes.
The event will take place in Fyvie Hall, 309 Regent Street London W1B 2HT.
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Professor Sigrun Lange
As Professor of Molecular Pathobiology at the University of Westminster, Sigrun leads a pioneering cross-disciplinary research programme, with a focus on post-translational citrullination and extracellular vesicle research in pathobiological processes and in shaping of immunology in evolution and adaption of the immune system.
Sigrun holds a BSc in Biology from the University of Iceland, a MSc from the Faculty of Medicine, University of Iceland, and a PhD from the Faculty of Medicine, University of Iceland, during which she was supported by the Icelandic Research Council, European Union, IUBMB and EMBO visiting research fellowships to the Arctic University Tromso, Norway, The University Hospital Basel, Switzerland and The University of Oxford. Sigrun received the Prof. Axelsson´s Young Investigators 2005 Award for advancing fundamental understanding in vertebrate immunity.
Having developed a special interest in tissue remodelling and regeneration, Sigrun then spent 9 post-doctoral years (2006 - 2015) at University College London in regenerative medicine and neuroscience where she identified peptidylarginine deiminases (PADs) and associated post-translational citrullination as novel players in nervous system regeneration and stem cell maintenance (UCL Institute of Child Health, 2006-2010 - funded by the BBSRC); as potential therapeutic targets in neo-natal brain repair (UCL Institute for Women’s Health, 2010-2013 - funded by Wellbeing of Women), and in neurodegenerative disease models and the modulation of extracelluar vesicle communication (UCL School of Pharmacy 2013-2015), while also participating in the EU Flagship Human Brain Project, funded by the European Commission for Future and Emerging Technology. In 2015, Sigrun received the Young Scientist Award from the Icelandic Biological Society.
Sigrun joined the University of Westminster as Lecturer in Molecular Pathology at the School of Life Sciences in 2016, was promoted to Senior Lecturer in 2017, to Reader in 2020 and to Professor in 2022. Sigrun leads the Tissue Architecture and Regeneration Research Group since 2017 and was in 2021 elected Fellow of The Royal Society of Biology (FRSB) for her distinctive and notable contribution to the advancement of biological sciences.
